Why Specific Genetic Alterations Matter in Prostate Cancer

A given substance may be fundamental for life or may serve as a poison. All depends on the specific dose. At first glance, this somewhat paradoxical principle in medicine was first coined by the Swiss physician Paracelsus more than half a millennium ago when he stated: “All things are poison, and nothing is without poison. Solely the dose determines that a thing is not a poison”. Centuries later, researchers at the Institute of Oncology Research in Bellinzona have discovered how these fundamenta...
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Important steps forward in the anti-ageing therapy against metastases

Congratulations to Prof. Alimonti and his Molecular Oncology team at Institute of Oncology Research in Bellinzona, Switzerland, who discovered a genetic factor that determines whether ageing prostate cancer cells either die or become more aggressive. They have now found the genetic switch that determines the fate of senescent cells: the gene TIMP1. If this gene is inactive or absent in patients, factors are released in the tumor cell which reprogram the cell and make it more aggressive and invas...
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Congratulations to Prof. Alimonti and his Molecular Oncology team on receiving the Prostate Cancer Foundation Challenge Award

Prof. Alimonti from the Institute of Oncology Research (IOR) in Bellinzona, Switzerland and Prof. De Bono from the Institute of Cancer Research (ICR) in London, United Kingdom, just received this prestigious award for their work on targeting the host microbiota to reverse therapeutic resistance in lethal prostate cancers. Microbiota are microorganisms living in symbiosis with the host reported to be fundamental to homeostasis; their perturbation, microbial dysbiosis, is documented in differen...
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PhD student position available in the Tumor Biology and Experimental Therapeutics group at the Institute of Oncology Research (IOR)

A PhD student position is available in the Tumor Biology and Experimental Therapeutics group headed by Prof. Carlo V. Catapano at the Institute of Oncology Research (IOR). We are looking for young, highly motivated and enthusiastic candidates interested in pursuing a PhD in cancer biology and therapy working in an active and competitive research environment. Main projects will deal with: Epigenetic and transcriptional pathways sustaining stem-like tumor-initiating cells Metabolic repr...
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POSITIONS AVAILABLE FOR RESEARCH ASSISTANT IN LYMPHOMA BIOLOGY

The Lymphoma Genomics Group headed by Prof. Francesco Bertoni at the Institute of Oncology Research (IOR) is seeking a RESEARCH ASSISTANT to study novel compounds in lymphomas. The candidate must have a BSc or equivalent degree with knowledge of lymphoma cell biology and signaling pathways. Candidate must possess laboratory experience in molecular and cell biology techniques. Experience with in vivo mouse xenograft models is advantageous. Excellent knowledge of English, good interpersonal...
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