New paper by Dr. Francesco Bertoni lab

news on 22 Oct , 2018
The research team led by Dr. Francesco Bertoni has discovered the potential role of Bromodomain and Extra Terminal domain (BET) inhibitor birabresib (MK-8628/OTX015) in treating mantle cell lymphoma (MCL) patients, which are still in need of therapeutic improvement. Innovative results have been published in ESMO Open journal. BET proteins act as transcriptional regulators of key signaling pathw...

New publication by Dr. Carbone’s laboratory

news on 1 Oct , 2018
A new study, published in European Urology Oncology, describes the in vitro and in vivo activity of EC-8042, a novel anticancer compound that interferes with transcriptional reprogramming and expansion of cancer stem cells in preclinical models of ERG positive prostate cancer. The study was carried out in collaboration with Entrechem (Oviedo, Spain). T...