New review article from Catapano and Carbone groups

news on 2 Jul , 2019
New review article from Catapano and Carbone groups focusing on transcriptional reprogramming in cancer stem cells. In this article, the authors evaluate the role of prostate cancer stem cells in disease progression and treatment resistance and the impact of transcriptional regulators on stemness-associated phenotypic reprogramming. Recent progress in this area supports the possibility of interfe...

15-ICML International Conference on Malignant Lymphoma

news on 30 Jun , 2019
Take a look at the healthbook 15-ICML Newsroom featuring video interviews with renowned experts in the fields of haematology/oncology and a selection of clinically relevant study highlights of the 15th International Conference on Malignant Lymphoma(15-ICML).

New review article by Prof. Francesco Bertoni on BET inhibitors

news on 17 Jun , 2019
Prof. Francesco Bertoni and his Colleague PD Anastasios Stathis of the Oncology Institute of Southern Switzerland (IOSI) has just been published a review article that summarizes the current knowledge on BET inhibitors in lymphomas. The article is based on the talk given at the 2018 “Inaugural AACR International Meeting Advances in Malignant Lymphoma”, a conference organized in cooperation with the...

Cancer research: IOR receives important grant

news on 12 Jun , 2019
Proteins in cells are subject to various chemical modifications that regulate their activity. One common modification consists in the attachment of ubiquitin molecules through a cascade of enzymes. Genetic defects in this ubiquitin cascade are the cause of many acquired and hereditary diseases, including neurodegenerative, immune and tumour disorders. Due to the complex biology and transient natur...

A new paper by Prof. Francesco Bertoni’s lab on a dual TORC1/2 inhibitor

news on 6 Jun , 2019
The research team led by Prof. Francesco Bertoni has published the results of a project in collaboration with the Group of Prof. Wymann at the University of Basel and the Colleagues at PIQUR Therapeutics in the journal Cancers. mTOR is an atypical serine/threonine kinase often aberrantly activated in cancer cells because it is central in the regulation of cellular growth and metabolism. It is p...

New paper from Catapano and Carbone groups

news on 24 May , 2019
The study published in Cell Metabolism reveals new way to eliminate cancer stem cells in prostate cancer and enhance treatment efficacy. The study conducted by investigators in the Catapano and Carbone groups at the Institute of Oncology Research (IOR, affiliated to USI Università della Svizzera italiana) in Bellinzona, Switzerland, finds a new way to eliminate cancer stem cells in prostate ca...