Sarah Natalia Mapelli awarded PhD

news on 7 Mar , 2019
Sarah Natalia Mapelli, computational researcher in the Tumor Biology and Experimental Therapeutics group, successfully defended her PhD on January 29th 2019, at Università della Svizzera Italiana (USI) within the SIB PhD training network. She presented her work "Deciphering the complexity of human noncoding promoter-proximal transcriptome: different scales of transcriptional control", derived from...

A new publication by Dr Francesco Bertoni LAB

news on 25 Feb , 2019
Antibody-drug conjugates (ADCs) are an effect therapeutic modality to deliver potent cytotoxic molecules to tumor cells bearing a specific antigen. A paper now published in Haematologica presents the novel anti-CD19 ADC huB4-DGN462, developed by Colleagues from Immunogen and characterized for its anti-lymphoma activity in Bertoni’s lab. As shown by the work of Chiara Tarantelli and her Colle...

IOR is proud to present his latest Group Leader

news on 18 Feb , 2019
The Institute of Oncology Research is proud to announce the designation of a new Group Leader: Dr. Arianna Calcinotto. Dr. Calcinotto obtained a PhD in Molecular Medicine with honors (Università Vita-Salute San Raffaele, Milan, IT) in 2015. During her PhD she spent a period in the laboratory of Leif Bergsagel (Mayo Clinic, Scottsdale, AZ, US). During these years, she has developed an ext...

Pfizer Foundation Research Prize 2019 – accolades for researchers in Ticino

news on 8 Feb , 2019
Yesterday evening, at a ceremony held in Zurich, the Pfizer Foundation awarded two prizes to research groups at the Institute for Research in Biomedicine (IRB) and at the Institute of Oncology Research (IOR), both affiliated to Università della Svizzera italiana (USI Faculty of Biomedical Sciences). Dr. Greta Guarda and Dr. Sonia Chelbi of the IRB received a prize for their research in the fiel...

New publication by Dr. Catapano’s group

news on 7 Feb , 2019
A new study, published in Bioinformatics, dissects the complexity of human noncoding promoter-proximal transcriptome. The study provides the first comprehensive analysis of the promoter-proximal transcriptome in the human genome and offers novel insights into the roles of promoter-associated transcripts or paRNAs in transcriptional control, epigenetic processes, chromatin architecture and human di...

New paper by Dr. Francesco Bertoni lab

news on 6 Feb , 2019
A new study led by Francesco Bertoni in collaboration with Francesco Forconi from the University of Southampton provides novel insights in the pathogenesis of hairy cell leukemia. Classic hairy cell leukemia (HCL) is a rare mature B cell tumor that is characterized by the acquisition of the BRAF V600E mutation, which leads to constitutive BRAF-MEK-ERK pathway activation and represents an effect...