New paper by Dr. Francesco Bertoni lab

news on 6 Feb , 2019
A new study led by Francesco Bertoni in collaboration with Francesco Forconi from the University of Southampton provides novel insights in the pathogenesis of hairy cell leukemia. Classic hairy cell leukemia (HCL) is a rare mature B cell tumor that is characterized by the acquisition of the BRAF V600E mutation, which leads to constitutive BRAF-MEK-ERK pathway activation and represents an effect...

New paper by Dr. Francesco Bertoni Lab

news on 28 Jan , 2019
Inhibition of Bruton's tyrosine kinase (BTK) is a well-established therapeutic approach in B-cell malignancies and two BTK inhibitors, ibrutinib and acalabrutinib, have been approved by the U.S. Food and Drug Administration (FDA). In this new work by Bertoni’s lab and published on Haematologica, Chiara Tarantelli and colleagues studied an investigational second generation irreversible BTK inhibito...

New Publication by Dr. Bertoni

news on 2 Jan , 2019
A publication in the Haematologica journal by Dr. Bertoni in collaboration with Prof. Luca Aresu of the Department of Veterinary Sciences from the University of Turin has paved the way to a new approach in biomedical research, highlighting the importance of the use of the dog as comparative and pre-clinical model in oncology medicine. Authors provide brand new data on transcriptomic, methylation a...