Group LeaderPhone: 091 821 0075
Email: jean-philippe -dot- theurillat -at- ior -dot- usi -dot- ch
My research focuses on how recently identified cancer driver mutations promote tumor growth. In prostate cancer, we discovered a genetically defined subclass of tumors characterized by point-mutations in SPOP (a substrate-binding subunit of a Cullin-based E3 ubiquitin ligase) and deletions in CHD1 (a chromodomain helicase DNA binding protein). Using systematic functional approaches we aim to decipher their precise roles in tumorigenesis with the ultimate goal to develop new therapeutic avenues for this subtype of the disease. Additionally, I’m devoted to develop strategies that enable us to test drug responses on patient-derived tumor cells in a clinical context.